An Assessment of Serological Assays for SARS-CoV-2 as Surrogates for Authentic Virus Neutralization

Author:

Wohlgemuth Nicholas1,Whitt Kendall2,Cherry Sean1,Kirkpatrick Roubidoux Ericka1,Lin Chun-Yang3,Allison Kim J.1,Gowen Ashleigh1,Freiden Pamela1,Allen E. Kaitlynn3,Gaur Aditya H.1,Estepp Jeremie H.45,Tang Li6,Mori Tomi6,Hijano Diego R.1,Hakim Hana1,McGargill Maureen A.3ORCID,Krammer Florian7ORCID,Whitt Michael A.2,Wolf Joshua1ORCID,Thomas Paul G.3,Schultz-Cherry Stacey1ORCID,

Affiliation:

1. Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

2. Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA

3. Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

4. Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

5. Department of Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

6. Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

7. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

The ongoing COVID-19 pandemic is caused by infection with severe acute respiratory syndrome virus 2 (SARS-CoV-2). Prior infection or vaccination can be detected by the presence of antibodies in the blood.

Funder

University of Tennessee Research Foundation

Private Donors

American Lebanese Syrian Associated Charities

American Society of Hematology

HHS | NIH | National Institute of Allergy and Infectious Diseases

JPB Foundation

Open Philanthropy Project

Steven and Alexandra Cohen Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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