Contemporary Evaluation of Tebipenem <i>In Vitro</i> Activity against Enterobacterales Clinical Isolates Causing Urinary Tract Infections in US Medical Centers (2019

Contemporary Evaluation of Tebipenem In Vitro Activity against Enterobacterales Clinical Isolates Causing Urinary Tract Infections in US Medical Centers (2019–2020)

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Mendes Rodrigo E.¹^ORCID,Arends S. J. Ryan¹^ORCID,Streit Jennifer M.¹^ORCID,Critchley Ian²,Cotroneo Nicole²^ORCID,Castanheira Mariana¹^ORCID

Affiliation:

1. JMI Laboratories, North Liberty, Iowa, USA

2. Spero Therapeutics, Cambridge, Massachusetts, USA

Abstract

The occurrence of urinary-tract Enterobacterales pathogens producing ESBL enzymes in community and nosocomial settings continues to increase, as does the coresistance to fluoroquinolones, trimethoprim-sulfamethoxazole and nitrofurantoin often exhibited by these pathogens. This scenario complicates the clinical empirical and guided management of UTI by precluding the use of oral and many intravenous options.

Funder

Spero Therapeutics

Department of Health and Human Services

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02057-22

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