Multiomics Analysis Reveals Aberrant Metabolism and Immunity Linked Gut Microbiota with Insomnia

Author:

Wang Qinghua12,Chen Bin34,Sheng Dashuang34,Yang Junjie5,Fu Shujie6,Wang Jingwen1,Zhao Changying347,Wang Yihui34,Gai Xiangzhen34,Wang Jianfeng7,Stirling Kyle8,Heng Xueyuan9,Man Honghao6,Zhang Lei34ORCID

Affiliation:

1. College of Life Science, Shandong Normal University, Jinan, China

2. School of Biological Science and Technology, University of Jinan, Jinan, China

3. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China

4. Microbiome-X, National Institute of Health Data Science of China & Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan, China

5. College of Life Science, Qilu Normal University, Jinan, China

6. Department of Neurology, Weihai Central Hospital Affiliated to Qingdao University, Weihai, China

7. Shandong Children’s Microbiome Center, Qilu Children's Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

8. Luddy School of Informatics, Computing and Engineering, Indiana University, Bloomington, Indiana, USA

9. Department of Neurosurgery, Lin Yi People’s Hospital, Linyi, China

Abstract

Our study indicated that systematic inflammation and metabolites might be a pathway linking the gut microbiome with insomnia. These findings provide new insights and a better understanding of gut microbiota's role in insomnia as well as potential novel microbiome-related etiologies for insomnia.

Funder

National Natural Science Foundation of China

TaiShan Industrial Experts Program

Taishan Scholar Program of Shandong Province

Shandong University Outstanding Young Scholars Program

Shandong Provincial Key Research and Development Program

Weihai Technique Extension Project

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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