Loss of a Branch Sugar in the Acinetobacter baumannii K3-Type Capsular Polysaccharide Due To Frameshifts in the <i>gtr6</i> Glycosyltransferase Gene Leads To Susceptibility To Phage APK37.1-Reference-Cited by-同舟云学术

Loss of a Branch Sugar in the Acinetobacter baumannii K3-Type Capsular Polysaccharide Due To Frameshifts in the gtr6 Glycosyltransferase Gene Leads To Susceptibility To Phage APK37.1

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Timoshina Olga Y.¹,Kasimova Anastasiya A.²,Shneider Mikhail M.¹,Arbatsky Nikolay P.²,Shashkov Alexander S.²,Shelenkov Andrey A.³,Mikhailova Yuliya V.³,Popova Anastasiya V.⁴^ORCID,Hall Ruth M.⁵^ORCID,Knirel Yuriy A.²,Kenyon Johanna J.⁶^ORCID

Affiliation:

1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

3. Central Scientific Research Institute of Epidemiology, Moscow, Russia

4. State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia

5. School of Life and Environmental Science, University of Sydney, Sydney, Australia

6. Centre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia

Abstract

Lytic bacteriophage have potential for the treatment of otherwise untreatable extensively antibiotic-resistant bacteria. For Acinetobacter baumannii , most phage exhibit specificity for the type of capsular polysaccharide (CPS) produced on the cell surface.

Funder

DHAC | National Health and Medical Research Council

Department of Education and Training | Australian Research Council

Russian Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03631-22

Reference45 articles.

1. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis