<i>In Vitro</i> and <i>In Vivo</i> Antimicrobial Activity of Hypochlorous Acid against Drug-Resistant and Biofilm-Producing Strains-Reference-Cited by-同舟云学术

In Vitro and In Vivo Antimicrobial Activity of Hypochlorous Acid against Drug-Resistant and Biofilm-Producing Strains

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Palau Marta¹²³^ORCID,Muñoz Estela¹^ORCID,Lujan Enric⁴^ORCID,Larrosa Nieves²³⁵^ORCID,Gomis Xavier¹³^ORCID,Márquez Ester⁶^ORCID,Len Oscar¹²³^ORCID,Almirante Benito¹²³^ORCID,Abellà Jordi⁴^ORCID,Colominas Sergi⁴^ORCID,Gavaldà Joan¹²³^ORCID

Affiliation:

1. Antibiotic Resistance Laboratory, Vall d’Hebron Research Institute (VHIR), Infectious Diseases Department, Vall d’Hebron University Hospital, Barcelona, Spain

2. Spanish Network for Research in Infectious Diseases (REIPI RD19/0016), Instituto de Salud Carlos III, Madrid, Spain

3. CIBERINFEC, ISCIII—CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain

4. Electrochemical Methods Laboratory-Analytical and Applied Chemistry Department, IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain

5. Microbiology Department, Vall d’Hebron University Hospital, Barcelona, Spain

6. Infectious Diseases Department, Vall d’Hebron University Hospital, Barcelona, Spain

Abstract

Currently, drug-resistant infections are increasing and there are fewer antibiotics available to treat them. Therefore, there is an urgent need to find new antibiotics and nonantimicrobial strategies to treat these infections. We present a new nonantibiotic strategy based on hypochlorous acid generation to treat long-term catheter-related and chronic wounds infections.

Funder

MEC | Instituto de Salud Carlos III

Fundació la Marató de TV3

"la Caixa" Foundation

Spanish Network for the Research in Infectious Disease

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02365-22

Reference46 articles.