Azithromycin Exposure Induces Transient Microbial Composition Shifts and Decreases the Airway Microbiota Resilience from Outdoor PM <sub>2.5</sub> Stress in Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled Trial-Reference-Cited by-全球学者库

Azithromycin Exposure Induces Transient Microbial Composition Shifts and Decreases the Airway Microbiota Resilience from Outdoor PM _2.5 Stress in Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled Trial

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Du Sisi¹²³,Shang Lianhan¹²³,Zou Xiaohui¹²³,Deng Xiaoyan¹²³⁴,Sun Aihua²³,Mu Shengrui¹²³,Zhao Jiankang¹²³,Wang Yimin¹²³⁵,Feng Xiaoxuan¹²³,Li Binbin¹²³,Wang Chunlei¹²³,Liu Shuai¹²³,Lu Binghuai¹²³^ORCID,Liu Yingmei¹²³,Zhang Rongrong⁶⁷,Tong Yigang⁶⁷,Cao Bin¹²³⁴⁸^ORCID

Affiliation:

1. China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine, Clinical Center for Pulmonary Infections, Capital Medical University, Beijing, China

2. Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

3. Department of Pulmonary and Critical Care Medicine, Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China

4. Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, China

5. Department of Pulmonary and Critical Care Medicine, Jin Yin-tan Hospital, Wuhan, Hubei, China

6. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

7. College of Information Science and Technology, Beijing University of Chemical Technology, Beijing, China

8. Changping Laboratory, Beijing, China

Abstract

The influence of antibiotic administration on the airway microbiota of healthy adults remains unknown. This study is a randomized, double-blind, placebo-controlled trial aiming to investigate the microbial shifts in airways after exposure to azithromycin among heathy adults.

Funder

The medical and health science technology innovation project of Chinese academy of medical sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02066-22

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