Combined Methylation and Transcriptome Analysis of Liver Injury of Nonalcoholic Fatty Liver Disease Induced by High Alcohol-Producing Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Combined Methylation and Transcriptome Analysis of Liver Injury of Nonalcoholic Fatty Liver Disease Induced by High Alcohol-Producing Klebsiella pneumoniae

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhang Rui¹²,Xu Ziying¹,Xue Guanhua¹²,Feng Junxia¹,Du Bing¹,Gan Lin¹,Fan Zheng¹,Fu Tongtong¹,Feng Yanling¹,Zhao Hanqing¹,Cui Jinghua¹,Yan Chao¹,Cui Xiaohu¹,Tian Ziyan¹,Chen Jinfeng¹,Yu Zihui¹,Yuan Jing¹²^ORCID

Affiliation:

1. Capital Institute of Pediatrics, Beijing, China

2. Children's Hospital Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Abstract

High alcohol-producing Klebsiella pneumoniae (HiAlc Kpn ) is one of causative agents of nonalcoholic fatty liver disease (NAFLD) and could induce liver damage. DNA methylation, as a common epigenetic form following contact with an etiologic agent and pathogenesis, can affect chromosome stability and transcription.

Funder

Feng foundation

BMSTC | Beijing Municipal Natural Science Foundation

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05323-22

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