Evolution of Virulence, Fitness, and Carbapenem Resistance Transmission in ST23 Hypervirulent Klebsiella pneumoniae with the Capsular Polysaccharide Synthesis Gene <i>wcaJ</i> Inserted via Insertion Sequence Elements-Reference-Cited by-同舟云学术

Evolution of Virulence, Fitness, and Carbapenem Resistance Transmission in ST23 Hypervirulent Klebsiella pneumoniae with the Capsular Polysaccharide Synthesis Gene wcaJ Inserted via Insertion Sequence Elements

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wang Shuyi¹²,Ding Qi¹,Zhang Yawei¹,Zhang Anru¹,Wang Qi¹,Wang Ruobing¹,Wang Xiaojuan¹,Jin Longyang¹,Ma Shuai¹²,Wang Hui¹²^ORCID

Affiliation:

1. Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, China

2. Institute of Medical Technology, Peking University Health Science Center, Beijing, China

Abstract

Klebsiella pneumoniae is one of the most common nosocomial pathogens worldwide, and we speculated that the evolution of the capsule might result in the convergence of carbapenem resistance and hypervirulence of K. pneumoniae . The wcaJ gene was first reported to be interrupted by insertion sequence elements in ST23-K1 hypervirulent Klebsiella pneumoniae , resulting in little capsule synthesis, which plays an important role in virulence.

Funder

National Natural Science Foundation of China

Newton Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02400-22

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