HopE and HopD Porin-Mediated Drug Influx Contributes to Intrinsic Antimicrobial Susceptibility and Inhibits Streptomycin Resistance Acquisition by Natural Transformation in Helicobacter pylori-Reference-Cited by-全球学者库

HopE and HopD Porin-Mediated Drug Influx Contributes to Intrinsic Antimicrobial Susceptibility and Inhibits Streptomycin Resistance Acquisition by Natural Transformation in Helicobacter pylori

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Liu Yixin¹²³,Yang Feng¹²³^ORCID,Wang Su¹,Chi Wenjing¹,Ding Li¹,Liu Tao¹,Zhu Feng¹,Ji Danian⁴,Zhou Jun⁴,Fang Yi¹,Zhang Jinghao¹,Xiang Ping⁴,Zhang Yanmei¹²³,Zhao Hu¹²³

Affiliation:

1. Department of Laboratory Medicine, Huadong Hospital, Fudan University, Shanghai, China

2. Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China

3. Research Center on Aging and Medicine, Fudan University, Shanghai, China

4. Department of Endoscopy, Huadong Hospital, Fudan University, Shanghai, China

Abstract

Helicobacter pylori is constitutively competent for natural transformation (NT) and possesses an efficient system for homologous recombination, which could be utilized to study the NT-mediated horizontal gene transfer induced antibiotic resistance acquisition. Bacterial porins have drawn renewed attention because of their crucial role in antibiotic susceptibility.

Funder

Shanghai Science and Technology Commission

National High Technology Research and Development Program of China

Shanghai Shenkang Hospital Development Center

Shanghai Health and Family Planning Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01987-21

Reference55 articles.