Drug-Resistant Characteristics, Genetic Diversity, and Transmission Dynamics of Rifampicin-Resistant Mycobacterium tuberculosis in Hunan, China, Revealed by Whole-Genome Sequencing

Author:

He Wencong1,Tan Yunhong2,Liu Chunfa3,Wang Yiting1,He Ping1,Song Zexuan1,Liu Dongxin34,Zheng Huiwen5,Ma Aijing1,Zhao Bing3,Ou Xichao3,Xia Hui3,Wang Shengfen3,Zhao Yanlin3ORCID

Affiliation:

1. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

2. Hunan Provincial Chest hospital, Tuberculosis Control Institution of Hunan province, Changsha, Hunan, China

3. National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing, China

4. Shenzhen Third People’s Hospital, Shenzhen City, Guangdong, China

5. Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

Abstract

Comprehensive information such as genetic background and drug-resistant profile of TB strains could help to tailor public interventions. However, these data are limited in Hunan province, one of the provinces with high-TB burden in China.

Funder

National Science and technology major project of infectious disease

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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