Characterization of Phage Resistance and Their Impacts on Bacterial Fitness in Pseudomonas aeruginosa

Author:

Li Na1,Zeng Yigang2,Wang Mengran1,Bao Rong3,Chen Yu1,Li Xiaoyu4,Pan Jue1,Zhu Tongyu2,Hu Bijie1,Tan Demeng2ORCID

Affiliation:

1. Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

2. Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

3. Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China

4. School of Bioengineering, Dalian University of Technology, Dalian, China

Abstract

Battling phage resistance is one of the main challenges faced by phage therapy. To overcome this challenge, detailed information about the mechanisms of phage-host interactions is required to understand the bacterial evolutionary processes.

Funder

National Natural Science Foundation of China

Shanghai Municipal Health Commission

Zhongshan Hospital

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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