Breadth and Durability of SARS-CoV-2-Specific T Cell Responses following Long-Term Recovery from COVID-19-Reference-Cited by-同舟云学术

Breadth and Durability of SARS-CoV-2-Specific T Cell Responses following Long-Term Recovery from COVID-19

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Dang Thi Thu Thao¹²,Anzurez Alitzel¹²,Nakayama-Hosoya Kaori¹,Miki Shoji¹,Yamashita Kazuo³,de Souza Mark¹,Matano Tetsuro¹²⁴,Kawana-Tachikawa Ai¹²⁴^ORCID

Affiliation:

1. AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan

2. Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

3. KOTAI Biotechnologies, Inc., Suita, Japan

4. Department of AIDS Vaccine Development, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Abstract

RNA viruses, including SARS-CoV-2, evade host immune responses through mutations. As broader T cell responses against multiple viral proteins could minimize the impact of each single amino acid mutation, the breadth of memory T cells would be one essential parameter for effective protection.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02143-23

Reference58 articles.

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2. Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

3. Early and Polyantigenic CD4 T Cell Responses Correlate with Mild Disease in Acute COVID-19 Donors

4. Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

5. Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

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