SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic Variants-Reference-Cited by-同舟云学术

SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic Variants

Published:2021-09-03 Issue:1 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sun Fengming¹²,Wang Xiuhua¹²,Tan Shun³,Dan Yunjie¹²,Lu Yanqiu³,Zhang Juan¹²,Xu Junli⁴,Tan Zhaoxia¹,Xiang Xiaomei¹,Zhou Yi¹,He Weiwei¹,Wan Xing¹,Zhang Wei¹,Chen Yaokai³,Tan Wenting¹²,Deng Guohong¹²^ORCID

Affiliation:

1. Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Army Medial University), Chongqing, China

2. Chongqing Key Laboratory for Research of Infectious Diseases, Chongqing, China

3. Division of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China

4. Beijing Novogene Company Limited, Beijing, China

Abstract

RNA virus population in a host does not consist of a consensus single haplotype but rather an ensemble of related sequences termed quasispecies. The dynamics of quasispecies afford SARS-CoV-2 a great ability on genetic fitness during intrahost evolution.

Funder

Chongqing Health Commission COVID-19 Project

TMMU COVID-19 Project

Youth Talent Medical Technology Program of PLA

Chinese Key Project Specialized for Infectious Diseases

TMMU key project for medical research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00261-21