Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae

Author:

Barkowsky Gina1,Abt Corina1,Pöhner Irina1,Bieda Adam1,Hammerschmidt Sven2,Jacob Anette34,Kreikemeyer Bernd1ORCID,Patenge Nadja1ORCID

Affiliation:

1. Institute of Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany

2. Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany

3. Peps4LS GmbH, Heidelberg, Germany

4. Functional Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany

Abstract

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and is responsible for the deaths of up to 2 million children each year. Antibiotic resistance and strain replacement by non-vaccine serotypes are growing problems.

Funder

Ministerium für Bildung, Wissenschaft und Kultur Mecklenburg-Vorpommern

Universität Rostock

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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