Evaluation of Aptamer Fluorescence Microscopy in the Diagnosis of Pulmonary Tuberculosis-Reference-Cited by-同舟云学术

Evaluation of Aptamer Fluorescence Microscopy in the Diagnosis of Pulmonary Tuberculosis

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zheng Ruijuan¹,Xu Feifan²,Huang Xiaochen¹,Wang Jie¹,Feng Yonghong¹,Huang Jin³,Qin Lianhua¹^ORCID

Affiliation:

1. Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

2. Department of Clinical Laboratory, The Sixth People’s Hospital of Nantong, Nantong, Jiangsu, China

3. Department of Biochemistry and Molecular Biology, Key Laboratory of Environmental Pollution Monitoring and Disease Control of Ministry of Education, Guizhou Medical University, Guiyang, Guizhou, China

Abstract

We established an aptamer fluorescence microscopy approach for rapid detection of MTB in clinical sputum samples. The use of aptamer probes was proven to significantly increase the sensitivity of sputum smear microscopy.

Funder

project of National Key R&D Program of China

National Natural Science Foundation of China

Opengning Project of Key Laboratory of Environmental Pollution Monitoring and Disease Control of Ministry of Education, Guizhou Medical University

Opengning Project of Key Laboratory of Enviromental Pollution Monitoring and Disease Control of Ministry of Education, Guizhou Medical University

Foundation of Nantong Sanitation and Health Committee

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02602-21

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