Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India

Author:

Shanmugam Siva Kumar1,Kumar Narender2,Sembulingam Tamilzhalagan1,Ramalingam Suresh Babu1,Selvaraj Ashok1,Rajendhiran Udhayakumar1,Solaiyappan Sudha1,Tripathy Srikanth P.1,Natrajan Mohan1,Chandrasekaran Padmapriyadarsini1,Swaminathan Soumya3,Parkhill Julian4ORCID,Peacock Sharon J.2,Ranganathan Uma Devi K.1ORCID

Affiliation:

1. Indian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis, Chennai, India

2. Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom

3. World Health Organization, Geneva, Switzerland

4. Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

Abstract

Current knowledge on resistance-conferring determinants in Mycobacterium tuberculosis is biased toward globally dominant lineages 2 and 4. In contrast, lineages 1 and 3 are predominant in India.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference42 articles.

1. World Health Organisation. 2020. Global tuberculosis report 2020. https://www.who.int/publications/i/item/9789240013131.

2. Central Tuberculosis Division. 2020. India TB report 2019. https://tbcindia.gov.in/WriteReadData/India%20TB%20Report%202019.pdf.

3. Implementation of the new integrated algorithm for diagnosis of drug-resistant tuberculosis in Karnataka State, India: How well are we doing?

4. Rapid diagnosis of drug-resistant TB using line probe assays: from evidence to policy

5. Evaluation of the GenoType MTBDR sl Version 2.0 Assay for Second-Line Drug Resistance Detection of Mycobacterium tuberculosis Isolates in South Africa

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