Complex Regulation of Gamma-Hemolysin Expression Impacts Staphylococcus aureus Virulence-Reference-Cited by-同舟云学术

Complex Regulation of Gamma-Hemolysin Expression Impacts Staphylococcus aureus Virulence

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Pivard Mariane¹^ORCID,Caldelari Isabelle²,Brun Virginie³⁴,Croisier Delphine⁵^ORCID,Jaquinod Michel³,Anzala Nelson⁵,Gilquin Benoît³⁴,Teixeira Chloé¹,Benito Yvonne⁶⁷,Couzon Florence¹,Romby Pascale²,Moreau Karen¹^ORCID,Vandenesch François¹⁶⁷^ORCID

Affiliation:

1. CIRI, Centre International de Recherche en Infectiologie, Université de Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, ENS de Lyon, Lyon, France

2. Architecture et Réactivité de l’ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France

3. Université Grenoble Alpes, Inserm, CEA, UMR BioSanté U1292, CNRS, CEA, Grenoble, France

4. Université Grenoble Alpes, CEA, LETI, Clinatec, Grenoble, France

5. Vivexia, Dijon, France

6. Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France

7. Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, Lyon, France

Abstract

S. aureus virulence in pneumonia results in its ability to produce several virulence factors, including the leucocidin PVL. Here, we demonstrate that HlgCB, another leucocidin, which targets the same receptors as PVL, highly contributes to S. aureus virulence in pvl -negative strains.

Funder

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01073-23

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