Identification of the BolA Protein Reveals a Novel Virulence Factor in K. pneumoniae That Contributes to Survival in Host-Reference-Cited by-同舟云学术

Identification of the BolA Protein Reveals a Novel Virulence Factor in K. pneumoniae That Contributes to Survival in Host

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhang Feiyang¹,Yan Xiangjin¹²,Bai Jiawei¹,Xiang Li¹,Ding Manlin¹,Li Qin¹,Zhang Biying¹,Liang Qinghua¹,Zhou Yingshun¹^ORCID

Affiliation:

1. Department of Pathogen Biology, School of Basic Medicine, Public Center of Experimental Technology of Pathogen Biology Technology Platform, Southwest Medical University, Luzhou, China

2. Department of Clinical Laboratory, Zigong First People’s Hospital, Zigong, China

Abstract

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and affects different pathways directly associated with bacterial virulence. Here, we unraveled the role of BolA in several phenotypes associated with the process of cell morphology, siderophore production, biofilm formation, cell adhesion, tissue colonization, and liver abscess.

Funder

National Natural Science Foundation of China

SPDST | Sichuan Province Science and Technology Support Program

Southwest Medical University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00378-22

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1. Community-Acquired Klebsiella pneumoniae Bacteremia: Global Differences in Clinical Patterns