Isolation of Carbapenem and Colistin Resistant Gram-Negative Bacteria Colonizing Immunocompromised SARS-CoV-2 Patients Admitted to Some Libyan Hospitals-Reference-Cited by-同舟云学术

Isolation of Carbapenem and Colistin Resistant Gram-Negative Bacteria Colonizing Immunocompromised SARS-CoV-2 Patients Admitted to Some Libyan Hospitals

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Slimene Khouloud¹²³⁴⁵,Ali Asrra A.⁶,Mohamed Elhussan A.⁷,El Salabi Allaaeddin⁶,Suliman Faraj S.⁷⁸,Elbadri Agela A.⁹¹⁰,El-fertas Fadi F.¹⁰,El-awjly Ahmed¹¹,Shokri Salah A.¹²,Rolain Jean-Marc¹²^ORCID,Chouchani Chedly³⁴⁵^ORCID

Affiliation:

1. Université Aix-Marseille, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, Marseille Cedex 05, France

2. IHU Méditerranée Infection, Marseille Cedex 05, France

3. Laboratoire des Microorganismes et Biomolécules Actives, Faculté des Sciences de Tunis, Campus Universitaire, 2098 El-Manar II, Université de Tunis El-Manar, Tunis, Tunisie

4. Laboratoire de Recherche des Sciences et Technologies de l’Environnement, Institut Supérieur des Sciences et Technologies de l’Environnement de Borj-Cedria, BP-1003, Hammam-Lif 2050, Université de Carthage, Tunisie

5. Unité de Service en Commun pour la Recherche Plateforme Génomique Institut Supérieur des Sciences et Technologies de l’Environnement de Borj-Cedria, BP-1003, Hammam-Lif 2050, Université de Carthage, Tunisie

6. Department of Environmental Health, Faculty of Public Health, University of Benghazi, Benghazi, Libya

7. Department of Community Medicine, Omar Al-Mukhtar University, El-Beyda, Libya

8. Almansoura Isolation Department of COVID-19 Patients, Shahat Teaching Hospital for Chest Diseases and Tuberculosis, Shahat, Libya

9. Department of Medicine, Faculty of Medicine, University of Benghazi, Benghazi, Libya

10. Alhawari Hospital, Benghazi, Libya

11. Sterilization Service Department, Benghazi Medical Center, Benghazi, Libya

12. Department of Microbiology, Faculty of Science, Misurata University, Misurata, Libya

Abstract

In this work, we describe, for the first time, the occurrence of carbapenem-resistant bacteria colonizing COVID-19 patients who developed hospital-associated infections with carbapenemase-producing, Gram-negative bacteria at some isolation centers of COVID-19 in the eastern part of Libya. Our results confirmed that the overuse of antimicrobials, such as carbapenem antibiotics, during the COVID-19 pandemic has led to the emergence of multidrug-resistant bacteria, mainly K. pneumoniae and A. baumannii , as well as colistin resistance.

Funder

IHU Mediterrannée Infection

Tunisian Ministry of Higher Education

Campus France

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02972-22

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