Update on SARS-CoV-2 Omicron Variant of Concern and Its Peculiar Mutational Profile-Reference-Cited by-同舟云学术

Update on SARS-CoV-2 Omicron Variant of Concern and Its Peculiar Mutational Profile

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Alkhatib Mohammad¹,Salpini Romina¹,Carioti Luca¹,Ambrosio Francesca Alessandra²,D’Anna Stefano¹,Duca Leonardo¹,Costa Giosuè²³,Bellocchi Maria Concetta¹,Piermatteo Lorenzo¹,Artese Anna²³,Santoro Maria Mercedes¹,Alcaro Stefano²³,Svicher Valentina⁴^ORCID,Ceccherini-Silberstein Francesca¹^ORCID

Affiliation:

1. Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy

2. Dipartimento di Scienze della Salute, Università degli Studi “Magna Graecia” di Catanzaro, Campus S. Venuta, Catanzaro, Italy

3. Net4Science Academic Spin-Off, Università Magna Græcia di Catanzaro, Campus S. Venuta, Catanzaro, Italy

4. Department of Biology, University of Rome Tor Vergata, Rome, Italy

Abstract

The Omicron variant of concern (VOC) has a peculiar spectrum of mutations characterized by the acquisition of mutations or deletions rarely detected in previously identified variants, particularly in the spike glycoprotein. Such mutations, mostly residing in the receptor-binding domain, could play a pivotal role in enhancing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity (by increasing binding affinity for ACE2), jeopardizing spike recognition by therapeutic and vaccine-induced antibodies and causing diagnostic assay failure.

Funder

Ministero dell'Istruzione, dell'Università e della Ricerca

EC | HORIZON EUROPE Framework Programme

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02732-21

Reference54 articles.

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2. European Centre for Disease Prevention and Control. 2021. Threat assessment brief: implications of the emergence and spread of the SARS-CoV-2 B.1.1. 529 variant of concern (Omicron) for the EU/EEA. https://www.ecdc.europa.eu/en/publications-data/threat-assessment-brief-emergence-sars-cov-2-variant-b.1.1.529.

3. Centers for Disease Control and Prevention. 2021. Science brief: Omicron (B.1.1.529) variant. https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/scientific-brief-omicron-variant.html.

4. Where did ‘weird’ Omicron come from?

5. Venkatakrishnan A Praveen A Patrick L Rohit S Bharathwaj R Michiel JN Venky S. 2021. Omicron variant of SARS-CoV-2 harbors a unique insertion mutation of putative viral or human genomic origin. OSF Preprints. https://doi.org/10.31219/osf.io/f7txy.

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