Serodominant SARS-CoV-2 Nucleocapsid Peptides Map to Unstructured Protein Regions-Reference-Cited by-同舟云学术

Serodominant SARS-CoV-2 Nucleocapsid Peptides Map to Unstructured Protein Regions

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Vandervaart Jacob P.¹²,Inniss Nicole L.¹³^ORCID,Ling-Hu Ted⁴,Minasov George¹³,Wiersum Grant¹³,Rosas-Lemus Monica¹³,Shuvalova Ludmilla³⁵,Achenbach Chad J.⁴^ORCID,Hultquist Judd F.⁴^ORCID,Satchell Karla J. F.¹²³^ORCID,Bachta Kelly E. R.⁴^ORCID

Affiliation:

1. Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

2. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

3. Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

4. Department of Medicine, Division of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

5. Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

Abstract

As SARS-CoV-2 continues to evolve, a structural and genetic understanding of key viral epitopes will be essential to the development of next-generation diagnostics and vaccines. This study uses structural biology and epitope mapping to define the antigenic regions of the viral nucleocapsid protein in sera from a cohort of COVID-19 patients with diverse clinical outcomes.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Cancer Institute

HHS | NIH | National Center for Advancing Translational Sciences

American Cancer Society

Dixon Family Foundation

Walder Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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