Fully Attenuated <i>meq</i> and <i>pp38</i> Double Gene Deletion Mutant Virus Confers Superior Immunological Protection against Highly Virulent Marek’s Disease Virus Infection-Reference-Cited by-同舟云学术

Fully Attenuated meq and pp38 Double Gene Deletion Mutant Virus Confers Superior Immunological Protection against Highly Virulent Marek’s Disease Virus Infection

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sun Aijun¹²,Zhao Xuyang¹²,Zhu Xiaojing¹²,Kong Zhengjie¹²,Liao Yifei³,Teng Man⁴⁵,Yao Yongxiu⁶⁷^ORCID,Luo Jun⁴⁵,Nair Venugopal⁶⁷,Zhuang Guoqing¹²^ORCID,Zhang Gaiping¹²⁴⁵⁸^ORCID

Affiliation:

1. College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, People’s Republic of China

2. International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, People’s Republic of China

3. Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

4. Key Laboratory of Animal Immunology, Ministry of Agriculture and Rural Affairs & Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, Henan, People’s Republic of China

5. UK-China Centre of Excellence for Research on Avian Diseases, Henan Academy of Agricultural Sciences, Zhengzhou, Henan, People’s Republic of China

6. Viral Oncogenesis Group,The Pirbright Institute, Pirbright, Surrey, United Kingdom

7. UK-China Centre of Excellence for Research on Avian Diseases, The Pirbright Institute, Pirbright, Surrey, United Kingdom

8. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou, People’s Republic of China

Abstract

MDV is a highly contagious immunosuppressive and neoplastic pathogen. The virus can be controlled through vaccination via an attenuated meq deletion mutant virus that retains the ability to induce lymphoid organ atrophy.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02871-22

Reference59 articles.

1. Pathogenesis of Marek’s disease virus infection;Calnek BW;Curr Top Microbiol Immunol,2001

2. Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis

3. Marek’s disease vaccines: Current status, and strategies for improvement and development of vector vaccines

4. Current status of virus-vectored vaccines against pathogens that affect poultry

5. Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. LORF9 of Marek’s disease virus is involved in the early cytolytic replication of B lymphocytes and can act as a target for gene deletion vaccine development;Journal of Virology;2023-12-21

2. The genome evolution of Marek’s disease viruses in chickens and turkeys in China;Virus Genes;2023-10-18

3. Mechanism of herpesvirus UL24 protein regulating viral immune escape and virulence;Frontiers in Microbiology;2023-09-22