FAM46C Is an Interferon-Stimulated Gene That Inhibits Lentiviral Particle Production by Modulating Autophagy-Reference-Cited by-同舟云学术

FAM46C Is an Interferon-Stimulated Gene That Inhibits Lentiviral Particle Production by Modulating Autophagy

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Mancino Marilena¹,Lai Giancarlo¹,De Grossi Federica²,Cuomo Alessandro³,Manganaro Lara¹⁴^ORCID,Butta Giacomo M.¹⁴,Ferrari Ivan¹,Vicenzi Elisa⁵^ORCID,Poli Guido⁵⁶,Pesce Elisa¹,Oliveto Stefania¹²,Biffo Stefano¹²^ORCID,Manfrini Nicola¹²^ORCID

Affiliation:

1. INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy

2. Department of Biosciences, University of Milan, Milan, Italy

3. Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy

4. Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

5. Viral Pathogenesis and Biosafety Unit, San Raffaele Scientific Institute, Milan, Italy

6. Vita-Salute San Raffaele University School of Medicine, Milan, Italy

Abstract

FAM46C role has been thoroughly investigated in MM, but studies characterizing its role outside of the tumoral environment are still lacking. Despite the success of antiretroviral therapy in suppressing HIV load to undetectable levels, there is currently no HIV cure, and treatment is lifelong.

Funder

Fondazione AIRC per la ricerca sul cancro ETS

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05211-22

Reference66 articles.

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5. Mapping of Chromosome 1p Deletions in Myeloma Identifies FAM46C at 1p12 and CDKN2C at 1p32.3 as Being Genes in Regions Associated with Adverse Survival

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