Metatranscriptomic Sequencing Reveals Host Species as an Important Factor Shaping the Mosquito Virome

Author:

Li Cixiu12,Liu Shuqi12,Zhou Hong12,Zhu Wei12,Cui Mingxue12,Li Juan12,Wang Jiao3,Liu Jiangyun3,Zhu Jin4,Li Weiping4,Bi Yuhai5,Carr Michael J.67ORCID,Holmes Edward C.8ORCID,Shi Weifeng29ORCID

Affiliation:

1. Department of Pathogen Biology, School of Clinical and Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, China

2. Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China

3. Mengla County Center for Disease Control and Prevention, Mengla, China

4. Xishuangbanna Prefecture Center for Disease Control and Prevention, Jinghong, China

5. Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

6. National Virus Reference Laboratory, School of Medicine, University College Dublin, Dublin, Ireland

7. International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

8. Sydney Institute for Infectious Diseases, School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia

9. School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, China

Abstract

This study revealed the huge capability of mosquitoes in harboring a rich diversity of RNA viruses, although relevant studies have characterized the intensively unparalleled diversity of RNA viruses previously. Furthermore, our findings showed discernible differences not only in viromic structure between mosquito genera and even between mosquito species within the same genus but also in the genetic diversity and abundance of Wolbachia between different mosquito populations.

Funder

National Natural Science Foundation of China

Youth Innovation Team of Shandong Higher Education Institution

Shandong First Medical University

Taishan Scholar Project of Shandong Province

Department of Education and Training | Australian Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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