Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension

Author:

Chen Bo-Yan123,Lin Wen-Zhen1234,Li Yu-Lin123,Bi Chao5,Du Lin-Juan123,Liu Yuan123,Zhou Lu-Jun1234,Liu Ting123,Xu Shuo123,Shi Chao-Ji236,Zhu Hong123,Wang Yong-Li123,Sun Jian-Yong123,Liu Yan123,Zhang Wu-Chang123,Zhang Zhiyuan236,Zhang Hui-li7,Zhu Ya-Qin234,Duan Sheng-Zhong123ORCID

Affiliation:

1. Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2. National Center for Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai, China

3. National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China

4. Department of General Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

5. Department of Stomatology, First Affiliated Hospital, Anhui Medical University, Hefei, China

6. Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

7. Department of Cardiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Abstract

Our study fills the gap in human studies investigating the oral and gut fungal microbiota in association with blood pressure. It characterizes the diversity and composition of the oral and gut fungal microbiome in human subjects, elucidates the dysbiosis of fungal ecology in a hypertensive population, and establishes oral-gut fungal correlations and fungus-clinical parameter correlations.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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