Gallium Nitrate Enhances Antimicrobial Activity of Colistin against Klebsiella pneumoniae by Inducing Reactive Oxygen Species Accumulation-Reference-Cited by-同舟云学术

Gallium Nitrate Enhances Antimicrobial Activity of Colistin against Klebsiella pneumoniae by Inducing Reactive Oxygen Species Accumulation

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Guo Mingjuan¹,Tian Ping²,Li Qingqing²,Meng Bao²,Ding Yuting²,Liu Yanyan²³⁴,Li Yasheng²³⁴,Yu Liang²³⁴,Li Jiabin¹²³⁴^ORCID

Affiliation:

1. Department of Infectious Disease, The Chaohu Affiliated Hospital of Anhui Medical University, Hefei, China

2. Department of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, China

3. Anhui Center for Surveillance of Bacterial Resistance, Hefei, China

4. Institute of Bacterial Resistance, Anhui Medical University, Hefei, Anhui, China

Abstract

This study aimed to determine the antimicrobial activity of GaNt combined with colistin against Klebsiella pneumoniae in vitro and in vivo . Our results suggest that by combining GaNt with colistin, antioxidant activity was suppressed and reactive oxygen species accumulation was induced in bacterial cells, enhancing antimicrobial activity against K. pneumoniae .

Funder

MOST | National Natural Science Foundation of China

安徽省教育厅 | University Natural Science Research Project of Anhui Province

China Postdoctoral Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00334-23

Reference58 articles.

1. World Health Organization. 2017. Global priority list of antibiotic-resistant bacteria guide to guide research, discovery, and development of new antibiotics, World Health Organization, Geneva, Switzerland.

2. Enterobacter spp.: Update on Taxonomy, Clinical Aspects, and Emerging Antimicrobial Resistance

3. The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae

4. Global Prevalence of Nosocomial Multidrug-Resistant Klebsiella pneumoniae: A Systematic Review and Meta-Analysis

5. Multidrug-resistantKlebsiella pneumoniae: challenges for treatment, prevention and infection control

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Promising treatments for refractory pneumonia caused by multidrug-resistant Klebsiella pneumoniae;Journal of Drug Delivery Science and Technology;2023-09

2. Gallium-based metal–organic frameworks loaded with antimicrobial peptides for synergistic killing of drug-resistant bacteria;Journal of Materials Chemistry B;2023