Safety Evaluation and Probiotic Potency Screening of Akkermansia muciniphila Strains Isolated from Human Feces and Breast Milk

Author:

Hou Fengyi12,Tang Jingyi12,Liu Yangyang3,Tan Yafang2,Wang Ye3,Zheng Lijun3,Liang Debao3,Lin Yuqing3,Wang Likun2,Pan Zhiyuan2,Yang Ruifu2,Bi Yujing2ORCID,Zhi Fachao1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China

2. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

3. Guangzhou ZhiYi Biotechnology Co., Ltd., Guangzhou, China

Abstract

In this study, we isolated 30 strains of Akkermansia muciniphila from different samples of human feces, and for the first time we isolated an A. muciniphila strain from human breast milk. This isolation verified the existence of microbes in human breast milk, which suggests that A. muciniphila can be vertically propagated from mother to infant and participates in the formation of the early gut microbiome.

Funder

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

The National Natural Science Foundation for Key Programs of China

The Innovation Leader Team Program of Guangzhou

R&D Plan for Key Areas in Guangdong Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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