Real-Life Feasibility of HIV Drug Resistance Testing Using Dried Filter Analytes in Kenyan Children and Adolescents Living with HIV-Reference-Cited by-同舟云学术

Real-Life Feasibility of HIV Drug Resistance Testing Using Dried Filter Analytes in Kenyan Children and Adolescents Living with HIV

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Manne Akarsh¹,DeLong Alexander¹,Nyandiko Winstone²³,DeLong Allison K.¹,Vreeman Rachel²⁴,Novitsky Vladimir¹,Ngeresa Anthony²,Sang Edwin²,Chory Ashley⁴,Aluoch Josephine²,Jepkemboi Eslyne²,Orido Millicent²,Ashimosi Celestine²,Sang Festus²,Hogan Joseph W.¹²,Kantor Rami¹²^ORCID,

Affiliation:

1. Brown University, Providence, Rhode Island, USA

2. Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya

3. Moi University College of Health Sciences, Eldoret, Kenya

4. Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

In this manuscript we use dried filter analytes shipped from Kenya to the US in real time, to demonstrate the real-life feasibility of conducting HIV drug resistance testing in a vulnerable population of young children and adolescents with HIV in a resource limited setting. Such testing, which is recommended in resource-rich settings, is unavailable in most resource limited settings for individual clinical care.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02675-21

Reference24 articles.

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2. World Health Organization. Global action plan on HIV drug resistance 2017–2021. http://who.int/hiv/pub/drugresistance/hivdr-action-plan-2017-2021/en/. Accessed September 10 2021.

3. Optimizing Research to Speed Up Availability of Pediatric Antiretroviral Drugs and Formulations

4. Alternative Sample Types for HIV-1 Antiretroviral Drug Resistance Testing

5. Dried Blood Spot Specimens Are a Suitable Alternative Sample Type for HIV-1 Viral Load Measurement and Drug Resistance Genotyping in Patients Receiving First-Line Antiretroviral Therapy