Genomic Epidemiology and Phylodynamic Analysis of Enterovirus A71 Reveal Its Transmission Dynamics in Asia

Author:

Xiao Jinbo1,Huang Keqiang1,Lu Huanhuan1,Song Yang1,Han Zhenzhi1,Zhang Man2,Li Jichen1,Zhou Xiaofang3,Chen Jianhua4,Yu Qiuli5,Yang Ming6,Yan Dongmei1,Ji Tianjiao1,Yang Qian1,Zhu Shuangli1,Xu Wenbo17,Zhang Yong17

Affiliation:

1. WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory of biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China

2. Shandong Center for Disease Control and Prevention, Jinan, Shandong, People’s Republic of China

3. Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People’s Republic of China

4. Gansu Center for Disease Control and Prevention, Lanzhou, Gansu, People’s Republic of China

5. Hebei Center for Disease Control and Prevention, Shijiazhuang, Hebei, People’s Republic of China

6. Heilongjiang Center for Disease Control and Prevention, Harbin, Heilongjiang, People’s Republic of China

7. Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, People’s Republic of China

Abstract

EV-A71 is one of the most important pathogens causing HFMD outbreaks; however, large-scale studies of EV-A71 genomic epidemiology are currently lacking. In this study, 200 new EV-A71 whole-genome sequences were determined.

Funder

MOST | National Key Research and Development Program of China

Natural Science Foundation of Beijing Municipality

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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