Computed Tomography Imaging for Monitoring of Marburg Virus Disease: a Nonhuman Primate Proof-Of-Concept Study

Author:

Sword Jennifer1,Lee Ji Hyun1,Castro Marcelo A.1ORCID,Solomon Jeffrey2,Aiosa Nina1,Reza Syed M. S.3,Chu Winston T.3ORCID,Johnson Joshua C.1,Bartos Christopher1,Cooper Kurt1,Jahrling Peter B.14,Johnson Reed F.14,Calcagno Claudia1,Crozier Ian2ORCID,Kuhn Jens H.1ORCID,Hensley Lisa E.1,Feuerstein Irwin M.1,Mani Venkatesh1ORCID

Affiliation:

1. Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, Fort Detrick, National Institutes of Health, Fort Detrick Frederick, Maryland, USA

2. Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

3. Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA

4. Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, USA

Abstract

Marburg virus (MARV) is a highly virulent zoonotic filovirid that causes Marburg virus disease (MVD) in humans. Much is unknown about disease progression and, thus, prevention and treatment options are limited.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Cancer Institute

HHS | NIH | NIH Clinical Center

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference77 articles.

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2. Kuhn JH, Amarasinghe GK, Perry DL. 2020. Filoviridae, p 449–503. In Howley PM, Knipe DM, Whelan SPJ (ed), Fields Virology, 7th ed., vol 1 (Emerging viruses). Lippincott Williams & Wilkins, Philadelphia, PA, USA.

3. Detection of Marburg Virus Disease in Guinea

4. World Health Organization. 2022. Ghana declares first-ever outbreak of Marburg virus disease. https://www.afro.who.int/countries/ghana/news/ghana-declares-first-ever-outbreak-marburg-virus-disease-0.

5. ProMED. 2023. Marburg virus disease - Equatorial Guinea (01): (KIE-NTEM) WHO confirmed. Archive Number: 20230214.8708367. https://promedmail.org/promed-post/?id=8708367.

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