Klebsiella Species and Enterobacter cloacae Isolates Harboring bla OXA-181 and bla OXA-48 : Resistome, Fitness Cost, and Plasmid Stability

Author:

Mahazu Samiratu12,Prah Isaac13,Ota Yusuke1,Hayashi Takaya3,Nukui Yoko45,Suzuki Masato6,Hoshino Yoshihiko7,Akeda Yukihiro8,Suzuki Toshihiko9,Ishino Tomoko2,Ablordey Anthony10,Saito Ryoichi14ORCID

Affiliation:

1. Department of Molecular Microbiology, Tokyo Medical and Dental University, Tokyo, Japan

2. Department of Parasitology and Tropical Medicine, Tokyo Medical and Dental University, Tokyo, Japan

3. Department of Molecular Virology, Tokyo Medical and Dental University, Tokyo, Japan

4. Department of Infection Control and Prevention, Tokyo Medical and Dental University Hospital, Tokyo, Japan

5. Department of Infection Control and Laboratory Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

6. Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan

7. Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan

8. Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan

9. Department of Bacterial Pathogenesis, Tokyo Medical and Dental University, Tokyo, Japan

10. Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana

Abstract

The growing rate of antibiotic resistance is an important global health threat. This threat is exacerbated by the lack of safe and potent alternatives to carbapenems in addition to the slow developmental process of newer and effective antibiotics.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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