HTLV-1 Proliferation after CD8 <sup>+</sup> Cell Depletion by Monoclonal Anti-CD8 Antibody Administration in Latently HTLV-1-Infected Cynomolgus Macaques-Reference-Cited by-同舟云学术

HTLV-1 Proliferation after CD8 ⁺ Cell Depletion by Monoclonal Anti-CD8 Antibody Administration in Latently HTLV-1-Infected Cynomolgus Macaques

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Nakamura-Hoshi Midori¹^ORCID,Nomura Takushi¹²,Nishizawa Masako¹,Hau Trang Thi Thu¹,Yamamoto Hiroyuki¹,Okazaki Midori¹,Ishii Hiroshi¹,Yonemitsu Kenzo³,Suzaki Yuriko³,Ami Yasushi³,Matano Tetsuro¹²⁴^ORCID

Affiliation:

1. AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan

2. Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

3. Management Department of Biosafety, Laboratory Animal, and Pathogen Bank, National Institute of Infectious Diseases, Tokyo, Japan

4. Institute of Medical Science, University of Tokyo, Tokyo, Japan

Abstract

HTLV-1 can cause serious diseases such as adult T-cell leukemia (ATL) in humans after chronic asymptomatic latent infection with substantial proviral load. Proviruses are detectable in peripheral lymphocytes in HTLV-1 carriers, and the association of a higher proviral load with a higher risk of disease progression has been observed.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01518-23

Reference44 articles.

1. HTLV-1: Persistence and pathogenesis

2. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

3. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

4. HTLV-I ASSOCIATED MYELOPATHY, A NEW CLINICAL ENTITY

5. ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS