Reliability of Genetic Alterations in Predicting Ceftriaxone Resistance in Neisseria gonorrhoeae Globally

Author:

Lin Eric Yu1ORCID,Adamson Paul C.2ORCID,Ha Sung-min3ORCID,Klausner Jeffrey D.4ORCID

Affiliation:

1. David Geffen School of Medicine at UCLA, Los Angeles, California, USA

2. Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA

3. Department of Integrative Biology and Physiology, UCLA, Los Angeles, California, USA

4. Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, California, USA

Abstract

Antimicrobial resistance in Neisseria gonorrhoeae ( N. gonorrhoeae ), the causative agent of gonorrhea, is rising globally. Ceftriaxone is the last remaining antibiotic for empirical treatment of gonorrhea.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference43 articles.

1. World Health Organization. 2018. Report on global sexually transmitted infection surveillance, 2018. Geneva, Switzerland.

2. Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to Ceftriaxone

3. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

4. World Health Organization. 2016. WHO guidelines for the treatment of Neisseria gonorrhoeae. World Health Organization Geneva. https://apps.who.int/iris/handle/10665/246114.

5. Japanese Society for Sexually Transmitted Infections. 2016. Guidelines for diagnosis and treatment of sexually transmitted diseases. Japan J of STIs.

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