USP1-Associated Factor 1 Modulates Japanese Encephalitis Virus Replication by Governing Autophagy and Interferon-Stimulated Genes

Author:

Xing Jinchao1234,Hu Chen1234,Che Siqi1,Lan Yixin12,Huang Lihong12,Liu Lele12,Yin Youqin123,Li Huanan23,Liao Ming1234ORCID,Qi Wenbao1234ORCID

Affiliation:

1. College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

2. Key Laboratory of Zoonosis, Ministry of Agriculture and Rural Affairs, Guangzhou, China

3. National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangzhou, China

4. Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, China

Abstract

Host factors play an essential role in virus replication and pathogenesis. Although UAF1 is well known to form complexes with ubiquitin-specific proteases, little is known about the function of the UAF1 protein itself.

Funder

MOST | National Key Research and Development Program of China

Project of Swine Innovation Team in Guangdong Modern Agricultural Research System

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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