Receptor-Binding-Motif-Targeted Sanger Sequencing: a Quick and Cost-Effective Strategy for Molecular Surveillance of SARS-CoV-2 Variants

Author:

Chaki Sankar Prasad1ORCID,Kahl-McDonagh Melissa M.1,Neuman Benjamin W.12,Zuelke Kurt A.1

Affiliation:

1. Texas A&M Global Health Research Complex, Division of Research, Texas A&M University, College Station, Texas, USA

2. Department of Biology, College of Science, Texas A&M University, College Station, Texas, USA

Abstract

The coronavirus disease 2019 (COVID-19) pandemic resulted in 427 million infections and 5.9 million deaths globally as of 21 February 2022. SARS-CoV-2, the causative agent of the COVID-19 pandemic, frequently mutates and has developed into variants of major public health concerns.

Funder

U.S. Department of Education

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference39 articles.

1. WHO. 2022. WHO coronavirus (COVID-19) dashboard. WHO Geneva Switzerland. https://covid19.who.int/.

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3. CDC. 2022. SARS-CoV-2 variant classifications and definitions. CDC Atlanta GA. https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-classifications.html.

4. The BNT162b2 (BioNTech/Pfizer) vaccine had 95% efficacy against COVID-19 ≥7 days after the 2nd dose

5. Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review

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