Differential Pneumococcal Growth Features in Severe Invasive Disease Manifestations

Author:

Arends Daan W.1ORCID,Alkema Wynand23,Hapsari Putri Indri14,van der Gaast–de Jongh Christa E.1,Eleveld Marc1,Langereis Jeroen D.1ORCID,de Mast Quirijn4,Meis Jacques F.5ORCID,de Jonge Marien I.1ORCID,Cremers Amelieke J. H.16ORCID

Affiliation:

1. Laboratory of Medical Immunology, Radboud Institute of Molecular Life Sciences, Radboudumc Center for Infectious Diseases, Radboudumc, Nijmegen, The Netherlands

2. TenWise BV, Leiden, The Netherlands

3. KCBBE, Institute for Life Science & Technology, Hanze University of Applied Sciences, Groningen, The Netherlands

4. Department of Internal Medicine, Radboud Institute of Health Sciences, Radboudumc Center for Infectious Diseases, Radboudumc, Nijmegen, The Netherlands

5. Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands

6. Department of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboudumc, Nijmegen, The Netherlands

Abstract

Streptococcus pneumoniae is a leading infectious cause of deaths worldwide. To understand the course and outcome of pneumococcal infection, most research has focused on the host and its response to contain bacterial growth.

Funder

Joint Programming Initiative More Years, Better Lives

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference67 articles.

1. Pathogenesis, treatment, and prevention of pneumococcal pneumonia

2. European Centre for Disease Prevention and Control. 2017. Invasive pneumococcal disease – Annual epidemiological report for 2015. https://www.ecdc.europa.eu/en/publications-data/invasive-pneumococcal-disease-annual-epidemiological-report-2015.

3. Centers for Disease Control and Prevention. 2015. Active bacterial core surveillance report emerging infections program network Streptococcus pneumoniae . https://www.cdc.gov/abcs/reports-findings/survreports/spneu15.html.

4. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015

5. Decline in Invasive Pneumococcal Disease after the Introduction of Protein–Polysaccharide Conjugate Vaccine

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