O-Antigen Diversification Masks Identification of Highly Pathogenic Shiga Toxin-Producing Escherichia coli O104:H4-Like Strains-Reference-Cited by-同舟云学术

O-Antigen Diversification Masks Identification of Highly Pathogenic Shiga Toxin-Producing Escherichia coli O104:H4-Like Strains

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Lang Christina¹,Fruth Angelika¹,Campbell Ian W.²^ORCID,Jenkins Claire³,Smith Peyton⁴,Strockbine Nancy⁴,Weill François-Xavier⁵,Nübel Ulrich⁶⁷⁸^ORCID,Grad Yonatan H.⁹^ORCID,Waldor Matthew K.²⁹¹⁰^ORCID,Flieger Antje¹^ORCID

Affiliation:

1. Division of Enteropathogenic Bacteria and Legionella, National Reference Centre for Salmonella and Other Enteric Bacterial Pathogens, Robert Koch Institut, Wernigerode, Germany

2. Department of Microbiology, Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

3. Gastro and Food Safety (One Health) Division, Health Security Agency, London, United Kingdom

4. Division of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

5. Institut Pasteur, Université Paris Cité, Unité des Bactéries Pathogènes Entériques, Paris, France

6. Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany

7. German Center for Infection Research (DZIF), Partner Site Braunschweig-Hannover, Hannover, Germany

8. Braunschweig Integrated Center of Systems Biology (BRICS), Technical University, Braunschweig, Germany

9. Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

10. Howard Hughes Medical Institute, Boston, Massachusetts, USA

Abstract

Our data suggest that the high-virulence ensemble of the STEC O104:H4 outbreak strain remains a global threat because genomically similar strains cause disease worldwide but that the horizontal acquisition of O-antigen gene clusters has diversified the O-antigens of strains belonging to ST678. Thus, the identification of these highly pathogenic strains is masked by diverse and rare O-antigens, thereby confounding the interpretation of their potential risk.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00987-23

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