Whole-Genome Sequencing for Resistance Prediction and Transmission Analysis of Mycobacterium tuberculosis Complex Strains from Namibia-Reference-Cited by-同舟云学术

Whole-Genome Sequencing for Resistance Prediction and Transmission Analysis of Mycobacterium tuberculosis Complex Strains from Namibia

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Claassens M.¹,Dreyer V.²³,Nepolo E.¹,Mokomele Q.⁴,van Rooyen G.⁴,Ruswa N.⁵,Günther G.¹⁶⁷,Niemann S.¹²³^ORCID

Affiliation:

1. Department of Human, Biological and Translational Medical Sciences, School of Medicine, University of Namibia, Windhoek, Namibia

2. Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany

3. German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany

4. Namibia Institute of Pathology Limited, Windhoek, Namibia

5. National Tuberculosis and Leprosy Programme, Windhoek, Namibia

6. Department of Pulmonology and Allergology, Inselspital Bern, Bern University Hospital, University of Bern, Bern, Switzerland

7. Katutura State Hospital, Ministry of Health and Social Services, Windhoek, Namibia

Abstract

The transmission of drug-resistant tuberculosis (TB) is a major problem for global TB control. Using genome sequencing, we showed that 13% of the multidrug-resistant (MDR) M. tuberculosis complex strains from Namibia are already pre-extensively drug resistant (pre-XDR), which is substantial in an African setting.

Funder

Bundesministerium für Gesundheit

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01586-22

Reference42 articles.

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2. World Health Organization. 2019. Global tuberculosis report 2019. World Health Organization, Geneva, Switzerland. https://www.who.int/tb/publications/global_report/en/.

3. World Health Organization. 2020. Global tuberculosis report 2020. World Health Organization, Geneva, Switzerland.

4. World Health Organization. 2021. Global tuberculosis report 2021. World Health Organization, Geneva, Switzerland. https://apps.who.int/iris/handle/10665/346387.

5. Ministry of Health and Social Services. 2019. Namibia tuberculosis disease prevalence survey—report 2019. National Tuberculosis and Leprosy Programme, Windhoek, Namibia.

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