Blockade-of-Binding Activities toward Envelope-Associated, Type-Specific Epitopes as a Correlative Marker for Dengue Virus-Neutralizing Antibody-Reference-Cited by-同舟云学术

Blockade-of-Binding Activities toward Envelope-Associated, Type-Specific Epitopes as a Correlative Marker for Dengue Virus-Neutralizing Antibody

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Keelapang Poonsook¹²^ORCID,Kraivong Romchat²³⁴⁵,Pulmanausahakul Rojjanaporn⁶,Sriburi Rungtawan¹²,Prompetchara Eakachai⁷⁸,Kaewmaneephong Jutamart¹,Charoensri Nicha⁹,Pakchotanon Pattarakul²³,Duangchinda Thaneeya²³⁴⁵,Suparattanagool Piyanan¹⁰,Luangaram Prasit²³,Masrinoul Promsin¹¹,Mongkolsapaya Juthathip⁴⁵¹²¹³,Screaton Gavin¹²¹³,Ruxrungtham Kiat⁷,Auewarakul Prasert¹⁴,Yoksan Sutee¹¹,Malasit Prida²³⁴⁵,Puttikhunt Chunya²³⁴⁵,Ketloy Chutitorn⁷⁸,Sittisombut Nopporn¹²^ORCID

Affiliation:

1. Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

2. Medical Biotechnology Research Unit, BIOTEC, NSTDA, Bangkok, Thailand

3. Molecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani, Thailand

4. Division of Dengue Hemorrhagic Fever Research, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

5. Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

6. Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand

7. Center of Excellence in Vaccine Research and Development (Chula-VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

8. Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

9. Center for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand

10. Clinical Epidemiology Unit, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

11. Center for Vaccine Development, Institute of Molecular Biosciences, Mahidol University at Salaya, Nakhon Pathom, Thailand

12. Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

13. Chinese Academy of Medical Science (CAMS), Oxford Institute (COI), University of Oxford, Oxford, United Kingdom

14. Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Abstract

This study describes a blockade-of-binding assay for the determination of antibodies that recognize a selected set of serotype-specific or group-reactive epitopes in the envelope of dengue virus. By employing blood samples collected from dengue virus-infected or -immunized macaques, moderate to strong correlations of the epitope-blocking activities with the virus-neutralizing antibody titers were observed with serotype-specific blocking activities for each of the four dengue serotypes.

Funder

National Science and Technology Development Agency

Thailand Research Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00918-23

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