Putative Familial Transmissible Bacteria of Various Body Niches Link with Home Environment and Children’s Immune Health

Author:

Zhao Lu1234,Chen Wanning56,Ge Yongsheng1,Lv Xin7,Wang Ying1,Yu Han1,Liu Yi1,Wu Dingfeng56,Jiao Na89,Wu Yuanqi5,Lv Daqing1011,Zhang Guoqing10,Xue Fuzhong23,Xu Xiaohong9,Gai Zhongtao1,Zhu Ruixin569ORCID,Zhang Lei123ORCID,Zhao Guoping101213

Affiliation:

1. Shandong Children’s Microbiome Center, Pediatric Research Institute, Qilu Children’s Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China

2. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China

3. National Institute of Health Data Science of China & Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China

4. Central Laboratory, the First Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of China

5. Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China

6. Bioinformatics Division, GloriousMed Clinical Laboratory Co., Ltd., Shanghai, People’s Republic of China

7. Laboratory Medicine, Qilu Children's Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China

8. Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

9. Research Institute, GloriousMed Clinical Laboratory Co., Ltd., Shanghai, People’s Republic of China

10. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China

11. Shanghai Shenyou Biotechnology Co. Ltd., Shanghai, People’s Republic of China

12. CAS Key Laboratory of Synthetic Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China

13. Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, People’s Republic of China

Abstract

Our study revealed that the children’s microbiota was partially transmitted from their family members and specific putative transmissible ASVs were associated with the immune system of children. These findings suggest that home life plays a key role in the shaping of young children’s microbiomes and has long-term health benefits.

Funder

Taishan Industrial Experts Program

National Natural Science Foundation of China

Shandong Provincial Key Research and Development Program

Shandong Provincial Natural Science Founfation

China Postdoctoral Science Foundation | National Postdoctoral Program for Innovative Talents of China

China Postdoctoral Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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