Intrathecal Synthesis Index of Specific Anti- <i>Treponema</i> IgG: a New Tool for the Diagnosis of Neurosyphilis-Reference-Cited by-同舟云学术

Intrathecal Synthesis Index of Specific Anti- Treponema IgG: a New Tool for the Diagnosis of Neurosyphilis

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Alberto Chloé¹^ORCID,Deffert Christine²,Lambeng Nathalie²,Breville Gautier³,Gayet-Ageron Angèle⁴,Lalive Patrice³,Toutous Trellu Laurence¹,Fontao Lionel¹²

Affiliation:

1. Division of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland

2. Division of Laboratory Medicine, University Hospital of Geneva, Geneva, Switzerland

3. Division of Neurology, University Hospital of Geneva, Geneva, Switzerland

4. CRC & Division of Clinical Epidemiology, Department of Health and Community Medicine, University of Geneva & University Hospitals of Geneva, Geneva, Switzerland

Abstract

In the context of a lack of a gold standard for the diagnosis of neurosyphilis due to either nonspecific or nonsensitive tests, we present in this article a new promising tool highly specific for NS diagnosis. This new test involves measuring an intrathecal synthesis index of specific anti- Treponema IgG by ELISA.

Funder

Swiss National Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01477-21

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