Coding and Noncoding Genomic Regions of Entamoeba histolytica Have Significantly Different Rates of Sequence Polymorphisms: Implications for Epidemiological Studies-Reference-Cited by-同舟云学术

Coding and Noncoding Genomic Regions of Entamoeba histolytica Have Significantly Different Rates of Sequence Polymorphisms: Implications for Epidemiological Studies

Published:2005-09 Issue:9 Volume:43 Page:4815-4819
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Bhattacharya Dhruva¹,Haque Rashidul²,Singh Upinder¹³

Affiliation:

1. Department of Microbiology and Immunology

2. Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

3. Department of Internal Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California 94305-5124

Abstract

ABSTRACT To evaluate genetic variability among Entamoeba histolytica strains, we sequenced 9,077 bp from each of 14 isolates. The polymorphism rates from coding and noncoding regions were significantly different (0.07% and 0.37%, respectively), indicating that these regions are subject to different selection pressures. Additionally, single nucleotide polymorphisms (SNPs) potentially associated with specific clinical outcomes were identified.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.43.9.4815-4819.2005

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