Complete Nucleotide Sequence of Klebsiella pneumoniae Multidrug Resistance Plasmid pKP048, Carrying bla KPC-2 , bla DHA-1 , qnrB4 , and armA-Reference-Cited by-全球学者库

Complete Nucleotide Sequence of Klebsiella pneumoniae Multidrug Resistance Plasmid pKP048, Carrying bla KPC-2 , bla DHA-1 , qnrB4 , and armA

Published:2010-09 Issue:9 Volume:54 Page:3967-3969
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jiang Yan¹,Yu Dongliang²³,Wei Zeqing⁴,Shen Ping⁴,Zhou Zhihui¹,Yu Yunsong¹

Affiliation:

1. Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016

2. James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou, Zhejiang 310008

3. Center of Biomedical and Health, Hangzhou Normal University, Hangzhou, Zhejiang 310012

4. State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China

Abstract

ABSTRACT The Klebsiella pneumoniae multidrug resistance plasmid pKP048 was completely sequenced. This plasmid carries several important resistance determinants, such as bla KPC-2 , bla DHA-1 , qnrB4 , and armA , which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively. Analysis of the finished 151,188-bp sequence data revealed 163 putative genes, 108 of which were assigned functions such as replication, stable inheritance, antibiotic resistance, a mobile element, conjugal transfer, and a restriction-modification system, showing the strong phylogenetic mosaicism and plasticity of the plasmid.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00137-10

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