Dual Effects of Let-7b in the Early Stage of Hepatitis C Virus Infection

Author:

Yeh Yung-Ju123,Tseng Ching-Ping456,Hsu Sheng-Da2,Huang His-Yuan789,Lai Michael M. C.310,Huang Hsien-Da289,Cheng Ju-Chien1ORCID

Affiliation:

1. Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan

2. Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

3. Research Center for Emerging Viruses, China Medical University Hospital, Taichung, Taiwan

4. Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan

5. Graduate Institute of Biomedical Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan

6. Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

7. Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan

8. School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, Shenzhen, Guangdong Province, China

9. Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Shenzhen, Guangdong Province, China

10. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan

Abstract

HCV is a leading cause of liver disease, with an estimated 71 million people infected worldwide. During HCV infection, type I interferon (IFN) signaling displays potent antiviral and immunomodulatory effects.

Funder

Ministry of Science and Technology, Taiwan

Chang Gung Medical Foundation

China Medical University, Taiwan

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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