Pleiotropic Effects of Influenza H1, H3, and B Baloxavir-Resistant Substitutions on Replication, Sensitivity to Baloxavir, and Interferon Expression-Reference-Cited by-全球学者库

Pleiotropic Effects of Influenza H1, H3, and B Baloxavir-Resistant Substitutions on Replication, Sensitivity to Baloxavir, and Interferon Expression

Published:2022-04-19 Issue:4 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hickerson Brady T.¹,Adams Simone E.¹,Barman Subrata²,Miller Lance²,Lugovtsev Vladimir Y.³,Webby Richard J.²,Ince William L.⁴,Donnelly Raymond P.¹^ORCID,Ilyushina Natalia A.¹^ORCID

Affiliation:

1. Division of Biotechnology Review and Research II, U.S. Food and Drug Administration, Silver Spring, Maryland, USA

2. Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

3. Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA

4. Division of Antiviral Products, U.S. Food and Drug Administration, Silver Spring, Maryland, USA

Abstract

Baloxavir is an anti-influenza endonuclease inhibitor that targets the polymerase acidic (PA) protein of influenza A and B viruses. Our knowledge regarding the pleiotropic effects of baloxavir resistance-associated substitutions is limited.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00009-22

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