Activity of Imipenem-Relebactam against Multidrug- and Extensively Drug-Resistant Burkholderia cepacia Complex and Burkholderia gladioli-Reference-Cited by-同舟云学术

Activity of Imipenem-Relebactam against Multidrug- and Extensively Drug-Resistant Burkholderia cepacia Complex and Burkholderia gladioli

Published:2021-10-18 Issue:11 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Becka Scott A.¹,Zeiser Elise T.¹,LiPuma John J.²^ORCID,Papp-Wallace Krisztina M.¹³^ORCID

Affiliation:

1. Research Service, VA Northeast Healthcare System, Cleveland, Ohio, USA

2. Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA

3. Departments of Medicine and Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

The Burkholderia cepacia complex (Bcc) and Burkholderia gladioli are opportunistic pathogens that most commonly infect persons with cystic fibrosis or compromised immune systems. Members of the Burkholderia genus are intrinsically multidrug resistant (MDR), possessing both a PenA carbapenemase and an AmpC β-lactamase, rendering treatment of infections due to these species problematic.

Funder

Cystic Fibrosis Foundation

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01332-21

Reference39 articles.

1. The various lifestyles of theBurkholderia cepaciacomplex species: a tribute to adaptation

2. Burkholderia cepacia complex: Beyond pseudomonas and acinetobacter