High-Level Carbapenem Resistance in OXA-232-Producing Raoultella ornithinolytica Triggered by Ertapenem Therapy-Reference-Cited by-同舟云学术

High-Level Carbapenem Resistance in OXA-232-Producing Raoultella ornithinolytica Triggered by Ertapenem Therapy

Published:2019-12-20 Issue:1 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Iovleva Alina¹,Mettus Roberta T.¹,McElheny Christi L.¹,Griffith Marissa P.¹,Mustapha Mustapha M.¹²^ORCID,Pasculle A. William³,Shields Ryan K.¹²,Cooper Vaughn S.²⁴^ORCID,Doi Yohei¹²⁵⁶

Affiliation:

1. Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

2. Center for Innovative Antimicrobial Therapy, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

3. Clinical Microbiology Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

4. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

5. Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

6. Department of Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

Abstract

OXA-232 is an OXA-48-group class D β-lactamase that hydrolyzes expanded-spectrum cephalosporins and carbapenems at low levels. Clinical strains producing OXA-232 are sometimes susceptible to carbapenems, making it difficult to identify them in the clinical microbiology laboratory.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01335-19

Reference21 articles.

1. CDC. 2018. Healthcare-associated infections: tracking CRE. https://www.cdc.gov/hai/organisms/cre/TrackingCRE.html. Accessed October 23 2018.

2. Emergence of Oxacillinase-Mediated Resistance to Imipenem in Klebsiella pneumoniae

3. OXA-48-like carbapenemases: the phantom menace