Class 1 Integrons Increase Trimethoprim-Sulfamethoxazole MICs against Epidemiologically Unrelated Stenotrophomonas maltophilia Isolates-Reference-Cited by-同舟云学术

Class 1 Integrons Increase Trimethoprim-Sulfamethoxazole MICs against Epidemiologically Unrelated Stenotrophomonas maltophilia Isolates

Published:2004-02 Issue:2 Volume:48 Page:666-669
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Barbolla Raquel¹,Catalano Mariana¹,Orman Betina E.¹,Famiglietti Angela²,Vay Carlos²,Smayevsky Jorgelina³,Centrón Daniela¹,Piñeiro Silvia A.¹

Affiliation:

1. Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina

2. Laboratorio de Bacteriología, Departamento de Análisis Clínicos, Hospital de Clínicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires

3. Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina

Abstract

ABSTRACT Twenty-five plasmid-specified antimicrobial resistance determinants common to gram-negative bacilli from nosocomial infection were investigated from 31 Stenotrophomonas maltophilia isolates. Twenty-four clones were identified by pulsed-field gel electrophoresis, and in three clones that exhibited an increased trimethoprim-sulfamethoxazole MIC, the sul1 determinant was found. These results support not only the higher spread of class 1 integrons compared to other mechanisms but also the potential limitation of using trimethoprim-sulfamethoxazole for therapy of severe S. maltophilia infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.2.666-669.2004

Reference20 articles.

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3. Plasmid Location and Molecular Heterogeneity of the L1 and L2 β-Lactamase Genes of Stenotrophomonas maltophilia

4. Genotypic and Phenotypic Relationships between Clinical and Environmental Isolates of Stenotrophomonas maltophilia

5. Bushby, S. R. 1973. Trimethoprim-sulfamethoxazole: in vitro microbiological aspects. J. Infect. Dis.128:442-462.

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