A Structure-Guided Genetic Modification Strategy: Developing Seneca Valley Virus Therapy against Nonsensitive Nonsmall Cell Lung Carcinoma-Reference-Cited by-全球学者库

A Structure-Guided Genetic Modification Strategy: Developing Seneca Valley Virus Therapy against Nonsensitive Nonsmall Cell Lung Carcinoma

Published:2023-05-31 Issue:5 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhao Zekai¹²,Cao Lin³⁴,Sun Zixian³⁵,Liu Wenqiang¹,Li Xiangmin¹²,Fang Kui¹,Shang Xianfei¹,Hu Junjie⁶,Chen Huanchun¹²,Lou Zhiyong³,Qian Ping¹²^ORCID

Affiliation:

1. National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, China

2. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China

3. Ministry of Education Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China

4. State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Response, College of Life Sciences, and State Key Laboratory of Medicinal Chemical Biology Nankai University, Tianjin, China

5. Department of Basic Research, Guangzhou Laboratory, Guangzhou, China

6. Hubei Colorectal Cancer Clinical Research Center, Hubei Cancer Hospital, Wuhan, China

Abstract

Nonsmall cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases (more than 1.85 million cases with 1.48 million deaths in 2020). In the present study, two novel oncolytic SVV mutants modified based on structural biology and reverse genetics (viral receptor-associated mutant SVV-S177A and viral antigenic peptide-related mutant SVV-S177A/P60S) with increased infectivity or lower immunogenicity significantly ( P < 0.001) prolonged the mOS from 11 days in the control cohort to 23 days in the SVV-S177A cohort and the SVV-S177A/P60S cohort in the NSCLC-bearing athymic mouse model, which may provide the direction for modifying SVV to improve the effect of oncolysis.

Funder

MOST | National Key R&D Program of China

National Natural Science Foundation of China

MOE | Fundamental Research Funds for the Central Universities

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00459-23

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