Molecular Basis of the Attenuation Exhibited by Molecularly Cloned Highly Passaged Chicken Anemia Virus Isolates-Reference-Cited by-同舟云学术

Molecular Basis of the Attenuation Exhibited by Molecularly Cloned Highly Passaged Chicken Anemia Virus Isolates

Published:2002-08-15 Issue:16 Volume:76 Page:8472-8474
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Todd Daniel¹,Scott Alistair N. J.²,Ball Neris W.¹,Borghmans Borghert J.¹,Adair Brian M.¹

Affiliation:

1. Department of Agriculture and Rural Development for Northern Ireland

2. Department of Veterinary Science, Veterinary Sciences Division, the Queen's University of Belfast, Stormont, Belfast BT4 3SD, United Kingdom

Abstract

ABSTRACT Chimeric virus experiments indicated that the pathogenicity and monoclonal antibody reactivity differences between two molecularly cloned, highly passaged chicken anemia virus isolates could be attributed to the VP1 amino acid change at residue 89. The introduction of this change into a pathogenic cloned low-passage isolate was not sufficient to cause attenuation.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.16.8472-8474.2002

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3. McNulty, M. S., T. J. Connor, F. McNeilly, and D. Spackman. 1989. Chicken anaemia agent in the United States: isolation of the virus and detection of antibody in broiler breeder flocks. Avian Dis. 33 : 691-694.

4. Meehan, B. M., D. Todd, J. L. Creelan, J. A. P. Earle, E. M. Hoey, and M. S. McNulty. 1992. Characterization of viral DNAs from cells infected with chicken anaemia agent: sequence analysis of the cloned replicative form and transfection capabilities of cloned genome fragments. Arch. Virol. 124 : 301-319.

5. Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle

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